From: ImmuneSupport.com
Martin L. Pall, PhD, is generating excitement in scientific communities worldwide with his theory that a "stressor-initiated" biochemical mechanism - the nitric oxide/peroxynitrite (NO/ONOO-) cycle - may be responsible for CFS, FM, and other syndromes.
In the following Q&A, Dr. Pall, Professor of Biochemistry and Basic Medical Sciences at Washington State University, explains his theory in lay terms. Simply put, Dr. Pall proposes that the complex NO/ONOO- cycle he describes may result in high levels of oxidants, which affect different tissues in different individuals, accounting for a “stunning” variety of symptoms. Dr. Pall also believes a well-chosen regimen of antioxidants and other agents may help the body “downregulate” the NO/ONOO- cycle biochemistry.
Q: Dr. Pall, you suggest that cases of chronic fatigue syndrome (CFS), fibromyalgia (FM), multiple chemical sensitivity (MCS) and post-traumatic stress disorder (PTSD) may all get started (get "initiated") by similar mechanisms. What led you to that conclusion?
Dr. Pall: Cases of each of these are initiated by certain short-term stressors. These include both bacterial and viral infections in CFS and FM, exposure to three types of pesticides or to organic solvents, in MCS, to physical trauma in FM or PTSD, or to severe psychological stress for PTSD or any of these others. There are others, totaling 12 or 13 such stressors.
Each of these diverse stressors can increase levels of a chemical compound called nitric oxide in the body. So I proposed that nitric oxide is likely to have a role in the initiation of chronic illness.
Q: So how can nitric oxide act to initiate chronic illness?
Dr. Pall: That is a very important question. I proposed that nitric oxide, acting via its product peroxynitrite, a potent oxidant, acts to initiate...
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Nitric Oxide Cycle Theory: Will It Explain CFS, FM, and Other 'Unexplained' Illnesses? - Q&A with Martin L. Pall, PhD
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Dr. Pall's Nitric Oxide Cycle Theory sheds light on complex illnesses like CFS, FM, and MCS, suggesting a unified mechanism behind their onset. His insights into the role of nitric oxide offer hope for effective treatments.
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